Übersicht über Forschung und Studien

40 Ergebnisse

Filtern nach Themenbereich:
Reizdarm-
syndrom (17)
Allergie (22)
Mikrobiom (4)
Filtern nach Themenbereich:
Reizdarm-
syndrom (17)
Allergie (22)
Mikrobiom (4)

Nr.

Kurztitel

Autoren

Quelle

Zusammenfassung

1

Aktuelle Methoden um Darmdurchlässigkeit zu messen

Schoultz, I., & Keita, Å. V. (2020). The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability. Cells, 9(8), 1909. https://doi.org/10.3390/cells9081909

2

American Gut Project zeigt Verbindung zwischen Allergien bei Erwachsenen und Darmmikrobiom

Hua, X., Goedert, J. J., Pu, A., Yu, G., & Shi, J. (2015). Allergy associations with the adult fecal microbiota: Analysis of the American Gut Project. EBioMedicine, 3, 172–179. https://doi.org/10.1016/j.ebiom.2015.11.038

3

Bedeutung von regulatorische T-Zellen für Allergietherapien

Palomares, O., Akdis, M., Martín-Fontecha, M., & Akdis, C. A. (2017). Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells. Immunological reviews, 278(1), 219–236. https://doi.org/10.1111/imr.12555

4

Darmdurchlässigkeit in Darmerkrankungen und Methoden um sie zu bestimmen

Vanuytsel, T., Tack, J., & Farre, R. (2021). The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation. Frontiers in nutrition, 8, 717925. https://doi.org/10.3389/fnut.2021.717925

5

Darmmikrobiom und verschiedene Erkrankungen

Afzaal, M., Saeed, F., Shah, Y. A., Hussain, M., Rabail, R., Socol, C. T., Hassoun, A., Pateiro, M., Lorenzo, J. M., Rusu, A. V., & Aadil, R. M. (2022). Human gut microbiota in health and disease: Unveiling the relationship. Frontiers in microbiology, 13, 999001. https://doi.org/10.3389/fmicb.2022.999001

6

Darmmikrobiomsignaturen von Kindern mit allergischer Rhinitis

Zhang, P., Zhou, X., Tan, H., Jian, F., Jing, Z., Wu, H., Zhang, Y., Luo, J., Zhang, J., & Sun, X. (2023). Microbial signature of intestine in children with allergic rhinitis. Frontiers in microbiology, 14, 1208816. https://doi.org/10.3389/fmicb.2023.1208816

7

Das Darmmikrobiom in allergischer Rhinits unterscheidet sich von anderen allergischen Erkrankungen

Su, Y. J., Luo, S. D., Hsu, C. Y., & Kuo, H. C. (2021). Differences in gut microbiota between allergic rhinitis, atopic dermatitis, and skin urticaria: A pilot study. Medicine, 100(9), e25091. https://doi.org/10.1097/MD.0000000000025091

8

Das Darmmikrobiom von Erwachsenen mit allergischer Rhinits ist weniger divers und hat eine reduzierte Vielfalt von Schlüsselbakterien

Watts, A. M., West, N. P., Zhang, P., Smith, P. K., Cripps, A. W., & Cox, A. J. (2021). The Gut Microbiome of Adults with Allergic Rhinitis Is Characterised by Reduced Diversity and an Altered Abundance of Key Microbial Taxa Compared to Controls. International archives of allergy and immunology, 182(2), 94–105. https://doi.org/10.1159/000510536

9

Der Effekt des Darmmikrobioms und Probiotika auf Gewicht und Fettleibigkeit

Aoun, A., Darwish, F., & Hamod, N. (2020). The Influence of the Gut Microbiome on Obesity in Adults and the Role of Probiotics, Prebiotics, and Synbiotics for Weight Loss. Preventive nutrition and food science, 25(2), 113–123. https://doi.org/10.3746/pnf.2020.25.2.113

10

Der Einfluss von Rauchen auf das Mikrobiom

Shapiro, H., Goldenberg, K., Ratiner, K., & Elinav, E. (2022). Smoking-induced microbial dysbiosis in health and disease. Clinical science (London, England : 1979), 136(18), 1371–1387. https://doi.org/10.1042/CS20220175

11

Der Zusammenhang von erhöhter Darmpermeabilität, Entzündung und Schmerzen beim Reizdarmsyndrom

Camilleri, M., Lasch, K., & Zhou, W. (2012). Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome. American journal of physiology. Gastrointestinal and liver physiology, 303(7), G775–G785. https://doi.org/10.1152/ajpgi.00155.2012

12

Die Adhäsion von B. bifidum MIMBb75 an Darmzellen wird nicht durch das bakterielle Oberflächenprotein BopA bestimmt, sondern beruht auf hydrophober Anziehung

Kainulainen, V., Reunanen, J., Hiippala, K., Guglielmetti, S., Vesterlund, S., Palva, A., & Satokari, R. (2013). BopA does not have a major role in the adhesion of Bifidobacterium bifidum to intestinal epithelial cells, extracellular matrix proteins, and mucus. Applied and environmental microbiology, 79(22), 6989–6997. https://doi.org/10.1128/AEM.01993-13

13

Die Adhäsion von Bifidobakterien an Darmgewebe

Westermann, C., Gleinser, M., Corr, S. C., & Riedel, C. U. (2016). A Critical Evaluation of Bifidobacterial Adhesion to the Host Tissue. Frontiers in microbiology, 7, 1220. https://doi.org/10.3389/fmicb.2016.01220

14

Die Rolle von regulatorischen T-Zellen in Allergien

Pellerin, L., Jenks, J. A., Bégin, P., Bacchetta, R., & Nadeau, K. C. (2014). Regulatory T cells and their roles in immune dysregulation and allergy. Immunologic research, 58(2-3), 358–368. https://doi.org/10.1007/s12026-014-8512-5

15

Die Rolle von regulatorischen T-Zellen in Allergien

Noval Rivas, M., & Chatila, T. A. (2016). Regulatory T cells in allergic diseases. The Journal of allergy and clinical immunology, 138(3), 639–652. https://doi.org/10.1016/j.jaci.2016.06.003

16

Dysbiose verursacht allergische Immunantworten

Augustine, T., Kumar, M., Al Khodor, S., & van Panhuys, N. (2023). Microbial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes. Clinical reviews in allergy & immunology, 65(1), 43–71. https://doi.org/10.1007/s12016-022-08939-9

17

Dysbiose verursacht nachhältige Veränderungen der Treg-Zellen im Körper

Zhang, X., Borbet, T. C., Fallegger, A., Wipperman, M. F., Blaser, M. J., & Müller, A. (2021). An Antibiotic-Impacted Microbiota Compromises the Development of Colonic Regulatory T Cells and Predisposes to Dysregulated Immune Responses. mBio, 12(1), e03335-20. https://doi.org/10.1128/mBio.03335-20

18

Effektivität und Sicherheit von Mikrobiomsupplementation in der Behandlung von allergischer Rhinitis

Liu, D., Wang, X., & Zhang, H. (2023). Efficacy and safety of gastrointestinal microbiome supplementation for allergic rhinitis: A systematic review and meta-analysis with trial sequential analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology, 118, 154948. https://doi.org/10.1016/j.phymed.2023.154948

19

Effektivität von Probiotika in der Behandlung von Kindern mit allergischer Rhinits

Wang, X., Tan, X., & Zhou, J. (2022). Effectiveness and safety of probiotic therapy for pediatric allergic rhinitis management: A systematic review and meta-analysis. International journal of pediatric otorhinolaryngology, 162, 111300. https://doi.org/10.1016/j.ijporl.2022.111300

20

Eigenschaften des Darmmikrobioms von Erwachsenen mit allergischer Rhinits

Zhu, L., Xu, F., Wan, W., Yu, B., Tang, L., Yang, Y., Du, Y., Chen, Z., & Xu, H. (2020). Gut microbial characteristics of adult patients with allergy rhinitis. Microbial cell factories, 19(1), 171. https://doi.org/10.1186/s12934-020-01430-0

21

Erhöhte Darmwanddurchlässigkeit steht in Verbindung mit Stuhlhäufigkeit beim Durchfall-prädomonaten Reizdarmsyndrom

Gecse, K., Róka, R., Séra, T., Rosztóczy, A., Annaházi, A., Izbéki, F., Nagy, F., Molnár, T., Szepes, Z., Pávics, L., Bueno, L., & Wittmann, T. (2012). Leaky gut in patients with diarrhea-predominant irritable bowel syndrome and inactive ulcerative colitis. Digestion, 85(1), 40–46. https://doi.org/10.1159/000333083

22

Erhöhte Darmwanddurchlässigkeit und Schmerzempfindlichkeit beim Durchfall-prädomonaten Reizdarmsyndrom

Zhou, Q., Zhang, B., & Verne, G. N. (2009). Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome. Pain, 146(1-2), 41–46. https://doi.org/10.1016/j.pain.2009.06.017

23

Immunmechanismen von Allergien und die Rolle der regulatorischen T-Zellen

Calzada, D., Baos, S., Cremades-Jimeno, L., & Cárdaba, B. (2018). Immunological Mechanisms in Allergic Diseases and Allergen Tolerance: The Role of Treg Cells. Journal of immunology research, 2018, 6012053. https://doi.org/10.1155/2018/6012053

24

Klinische Studie zur Behandlung des Reizdarmsyndroms mit B. bifidum HI-MIMBb75

Andresen, V., Gschossmann, J., & Layer, P. (2020). Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. The lancet. Gastroenterology & hepatology, 5(7), 658–666. https://doi.org/10.1016/S2468-1253(20)30056-X

25

Klinische Studie zur Behandlung des Reizdarmsyndroms mit B. bifidum MIMBb75 (lebender Stamm)

Guglielmetti, S., Mora, D., Gschwender, M., & Popp, K. (2011). Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study. Alimentary pharmacology & therapeutics, 33(10), 1123–1132. https://doi.org/10.1111/j.1365-2036.2011.04633.x

26

Laktobazillen in der Behandlung von allergischer Rhinitis

Steiner, N. C., & Lorentz, A. (2021). Probiotic Potential of Lactobacillus Species in Allergic Rhinitis. International archives of allergy and immunology, 182(9), 807–818. https://doi.org/10.1159/000515352

27

Messen von Darmwanddurchlässigkeit mit moderner transkutaner Floureszenzspektroskopie

Gan, J., Monfort Sánchez, E., Avery, J., Barbouti, O., Hoare, J., Ashrafian, H., Darzi, A., & Thompson, A. J. (2022). Non-invasive assessment of intestinal permeability in healthy volunteers using transcutaneous fluorescence spectroscopy. Methods and applications in fluorescence, 10(4), 10.1088/2050-6120/ac9513. https://doi.org/10.1088/2050-6120/ac9513

28

Probiotika

Kim, S. K., Guevarra, R. B., Kim, Y. T., Kwon, J., Kim, H., Cho, J. H., Kim, H. B., & Lee, J. H. (2019). Role of Probiotics in Human Gut Microbiome-Associated Diseases. Journal of microbiology and biotechnology, 29(9), 1335–1340. https://doi.org/10.4014/jmb.1906.06064

29

Probiotika in der Behandlung von allergischer Rhinitis

Luo, C., Peng, S., Li, M., Ao, X., & Liu, Z. (2022). The Efficacy and Safety of Probiotics for Allergic Rhinitis: A Systematic Review and Meta-Analysis. Frontiers in immunology, 13, 848279. https://doi.org/10.3389/fimmu.2022.848279

30

Probiotika modulieren Immunreaktionen in allergischen Erkrankungen

Eslami, M., Bahar, A., Keikha, M., Karbalaei, M., Kobyliak, N. M., & Yousefi, B. (2020). Probiotics function and modulation of the immune system in allergic diseases. Allergologia et immunopathologia, 48(6), 771–788. https://doi.org/10.1016/j.aller.2020.04.005

31

Sichtbare Lücken in der Darmbarriere beim Reizdarmsyndrom festgestellt mit konfokaler Laser-Endomikroskopie

Turcotte, J. F., Kao, D., Mah, S. J., Claggett, B., Saltzman, J. R., Fedorak, R. N., & Liu, J. J. (2013). Breaks in the wall: increased gaps in the intestinal epithelium of irritable bowel syndrome patients identified by confocal laser endomicroscopy (with videos). Gastrointestinal endoscopy, 77(4), 624–630. https://doi.org/10.1016/j.gie.2012.11.006

32

Sichtbare strukturelle Veränderungen der Darmbarriere im Durchfall-prädominaten Reizdarmsyndrom

Martínez, C., Lobo, B., Pigrau, M., Ramos, L., González-Castro, A. M., Alonso, C., Guilarte, M., Guilá, M., de Torres, I., Azpiroz, F., Santos, J., & Vicario, M. (2013). Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier. Gut, 62(8), 1160–1168. https://doi.org/10.1136/gutjnl-2012-302093

33

Stoffwechselprodukte von Darmbakterien modulieren Treg-Zellen

Calvo-Barreiro, L., Zhang, L., Abdel-Rahman, S. A., Naik, S. P., & Gabr, M. (2023). Gut Microbial-Derived Metabolites as Immune Modulators of T Helper 17 and Regulatory T Cells. International journal of molecular sciences, 24(2), 1806. https://doi.org/10.3390/ijms24021806

34

Strukturelle Veränderungen der Darmbarriere stehen in Verbindung mit Symptomeschwere beim RDS-Subtyp alternierende Symptome

Wilcz-Villega, E., McClean, S., & O'Sullivan, M. (2014). Reduced E-cadherin expression is associated with abdominal pain and symptom duration in a study of alternating and diarrhea predominant IBS. Neurogastroenterology and motility, 26(3), 316–325. https://doi.org/10.1111/nmo.12262

35

Studie II zur Adhesionsfähigkeit von B. bifidum MIMBb75 an Darmzellen

Guglielmetti, S., Tamagnini, I., Minuzzo, M., Arioli, S., Parini, C., Comelli, E., & Mora, D. (2009). Study of the adhesion of Bifidobacterium bifidum MIMBb75 to human intestinal cell lines. Current microbiology, 59(2), 167–172. https://doi.org/10.1007/s00284-009-9415-x

36

Studie zur Adhesionsfähigkeit von B. bifidum MIMBb75 an Darmzellen

Guglielmetti, S., Tamagnini, I., Mora, D., Minuzzo, M., Scarafoni, A., Arioli, S., Hellman, J., Karp, M., & Parini, C. (2008). Implication of an outer surface lipoprotein in adhesion of Bifidobacterium bifidum to Caco-2 cells. Applied and environmental microbiology, 74(15), 4695–4702. https://doi.org/10.1128/AEM.00124-08

37

Techniken und Biomarker um Darmdurchlässigkeit non-invasiv zu messen

Perez-Diaz-Del-Campo, N., Castelnuovo, G., Ribaldone, D. G., & Caviglia, G. P. (2023). Fecal and Circulating Biomarkers for the Non-Invasive Assessment of Intestinal Permeability. Diagnostics (Basel, Switzerland), 13(11), 1976. https://doi.org/10.3390/diagnostics13111976

38

Verbindung zwischen Darmbakterien und allergischen Erkrankungen

Han, P., Gu, J. Q., Li, L. S., Wang, X. Y., Wang, H. T., Wang, Y., Chang, C., & Sun, J. L. (2021). The Association Between Intestinal Bacteria and Allergic Diseases-Cause or Consequence?. Frontiers in cellular and infection microbiology, 11, 650893. https://doi.org/10.3389/fcimb.2021.650893

39

Veränderungen des Darmmikrobioms bei Kindern mit allergischen Atemwegserkrankungen

Wan, J., Song, J., Lv, Q., Zhang, H., Xiang, Q., Dai, H., Zheng, H., Lin, X., & Zhang, W. (2023). Alterations in the Gut Microbiome of Young Children with Airway Allergic Disease Revealed by Next-Generation Sequencing. Journal of asthma and allergy, 16, 961–972. https://doi.org/10.2147/JAA.S422537

40

Zerstörung der Darmbarriere durch erhöhte Aktivität von Enzymen verursacht Symptome in RDS-C

Annaházi, A., Ferrier, L., Bézirard, V., Lévêque, M., Eutamène, H., Ait-Belgnaoui, A., Coëffier, M., Ducrotté, P., Róka, R., Inczefi, O., Gecse, K., Rosztóczy, A., Molnár, T., Ringel-Kulka, T., Ringel, Y., Piche, T., Theodorou, V., Wittmann, T., & Bueno, L. (2013). Luminal cysteine-proteases degrade colonic tight junction structure and are responsible for abdominal pain in constipation-predominant IBS. The American journal of gastroenterology, 108(8), 1322–1331. https://doi.org/10.1038/ajg.2013.152

1

Aktuelle Methoden um Darmdurchlässigkeit zu messen

Schoultz, I., & Keita, Å. V. (2020). The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability. Cells, 9(8), 1909. https://doi.org/10.3390/cells9081909

2

American Gut Project zeigt Verbindung zwischen Allergien bei Erwachsenen und Darmmikrobiom

Hua, X., Goedert, J. J., Pu, A., Yu, G., & Shi, J. (2015). Allergy associations with the adult fecal microbiota: Analysis of the American Gut Project. EBioMedicine, 3, 172–179. https://doi.org/10.1016/j.ebiom.2015.11.038

3

Bedeutung von regulatorische T-Zellen für Allergietherapien

Palomares, O., Akdis, M., Martín-Fontecha, M., & Akdis, C. A. (2017). Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells. Immunological reviews, 278(1), 219–236. https://doi.org/10.1111/imr.12555

4

Darmdurchlässigkeit in Darmerkrankungen und Methoden um sie zu bestimmen

Vanuytsel, T., Tack, J., & Farre, R. (2021). The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation. Frontiers in nutrition, 8, 717925. https://doi.org/10.3389/fnut.2021.717925

5

Darmmikrobiom und verschiedene Erkrankungen

Afzaal, M., Saeed, F., Shah, Y. A., Hussain, M., Rabail, R., Socol, C. T., Hassoun, A., Pateiro, M., Lorenzo, J. M., Rusu, A. V., & Aadil, R. M. (2022). Human gut microbiota in health and disease: Unveiling the relationship. Frontiers in microbiology, 13, 999001. https://doi.org/10.3389/fmicb.2022.999001

6

Darmmikrobiomsignaturen von Kindern mit allergischer Rhinitis

Zhang, P., Zhou, X., Tan, H., Jian, F., Jing, Z., Wu, H., Zhang, Y., Luo, J., Zhang, J., & Sun, X. (2023). Microbial signature of intestine in children with allergic rhinitis. Frontiers in microbiology, 14, 1208816. https://doi.org/10.3389/fmicb.2023.1208816

7

Das Darmmikrobiom in allergischer Rhinits unterscheidet sich von anderen allergischen Erkrankungen

Su, Y. J., Luo, S. D., Hsu, C. Y., & Kuo, H. C. (2021). Differences in gut microbiota between allergic rhinitis, atopic dermatitis, and skin urticaria: A pilot study. Medicine, 100(9), e25091. https://doi.org/10.1097/MD.0000000000025091

8

Das Darmmikrobiom von Erwachsenen mit allergischer Rhinits ist weniger divers und hat eine reduzierte Vielfalt von Schlüsselbakterien

Watts, A. M., West, N. P., Zhang, P., Smith, P. K., Cripps, A. W., & Cox, A. J. (2021). The Gut Microbiome of Adults with Allergic Rhinitis Is Characterised by Reduced Diversity and an Altered Abundance of Key Microbial Taxa Compared to Controls. International archives of allergy and immunology, 182(2), 94–105. https://doi.org/10.1159/000510536

9

Der Effekt des Darmmikrobioms und Probiotika auf Gewicht und Fettleibigkeit

Aoun, A., Darwish, F., & Hamod, N. (2020). The Influence of the Gut Microbiome on Obesity in Adults and the Role of Probiotics, Prebiotics, and Synbiotics for Weight Loss. Preventive nutrition and food science, 25(2), 113–123. https://doi.org/10.3746/pnf.2020.25.2.113

10

Der Einfluss von Rauchen auf das Mikrobiom

Shapiro, H., Goldenberg, K., Ratiner, K., & Elinav, E. (2022). Smoking-induced microbial dysbiosis in health and disease. Clinical science (London, England : 1979), 136(18), 1371–1387. https://doi.org/10.1042/CS20220175

11

Der Zusammenhang von erhöhter Darmpermeabilität, Entzündung und Schmerzen beim Reizdarmsyndrom

Camilleri, M., Lasch, K., & Zhou, W. (2012). Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome. American journal of physiology. Gastrointestinal and liver physiology, 303(7), G775–G785. https://doi.org/10.1152/ajpgi.00155.2012

12

Die Adhäsion von B. bifidum MIMBb75 an Darmzellen wird nicht durch das bakterielle Oberflächenprotein BopA bestimmt, sondern beruht auf hydrophober Anziehung

Kainulainen, V., Reunanen, J., Hiippala, K., Guglielmetti, S., Vesterlund, S., Palva, A., & Satokari, R. (2013). BopA does not have a major role in the adhesion of Bifidobacterium bifidum to intestinal epithelial cells, extracellular matrix proteins, and mucus. Applied and environmental microbiology, 79(22), 6989–6997. https://doi.org/10.1128/AEM.01993-13

13

Die Adhäsion von Bifidobakterien an Darmgewebe

Westermann, C., Gleinser, M., Corr, S. C., & Riedel, C. U. (2016). A Critical Evaluation of Bifidobacterial Adhesion to the Host Tissue. Frontiers in microbiology, 7, 1220. https://doi.org/10.3389/fmicb.2016.01220

14

Die Rolle von regulatorischen T-Zellen in Allergien

Pellerin, L., Jenks, J. A., Bégin, P., Bacchetta, R., & Nadeau, K. C. (2014). Regulatory T cells and their roles in immune dysregulation and allergy. Immunologic research, 58(2-3), 358–368. https://doi.org/10.1007/s12026-014-8512-5

15

Die Rolle von regulatorischen T-Zellen in Allergien

Noval Rivas, M., & Chatila, T. A. (2016). Regulatory T cells in allergic diseases. The Journal of allergy and clinical immunology, 138(3), 639–652. https://doi.org/10.1016/j.jaci.2016.06.003

16

Dysbiose verursacht allergische Immunantworten

Augustine, T., Kumar, M., Al Khodor, S., & van Panhuys, N. (2023). Microbial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes. Clinical reviews in allergy & immunology, 65(1), 43–71. https://doi.org/10.1007/s12016-022-08939-9

17

Dysbiose verursacht nachhältige Veränderungen der Treg-Zellen im Körper

Zhang, X., Borbet, T. C., Fallegger, A., Wipperman, M. F., Blaser, M. J., & Müller, A. (2021). An Antibiotic-Impacted Microbiota Compromises the Development of Colonic Regulatory T Cells and Predisposes to Dysregulated Immune Responses. mBio, 12(1), e03335-20. https://doi.org/10.1128/mBio.03335-20

18

Effektivität und Sicherheit von Mikrobiomsupplementation in der Behandlung von allergischer Rhinitis

Liu, D., Wang, X., & Zhang, H. (2023). Efficacy and safety of gastrointestinal microbiome supplementation for allergic rhinitis: A systematic review and meta-analysis with trial sequential analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology, 118, 154948. https://doi.org/10.1016/j.phymed.2023.154948

19

Effektivität von Probiotika in der Behandlung von Kindern mit allergischer Rhinits

Wang, X., Tan, X., & Zhou, J. (2022). Effectiveness and safety of probiotic therapy for pediatric allergic rhinitis management: A systematic review and meta-analysis. International journal of pediatric otorhinolaryngology, 162, 111300. https://doi.org/10.1016/j.ijporl.2022.111300

20

Eigenschaften des Darmmikrobioms von Erwachsenen mit allergischer Rhinits

Zhu, L., Xu, F., Wan, W., Yu, B., Tang, L., Yang, Y., Du, Y., Chen, Z., & Xu, H. (2020). Gut microbial characteristics of adult patients with allergy rhinitis. Microbial cell factories, 19(1), 171. https://doi.org/10.1186/s12934-020-01430-0

21

Erhöhte Darmwanddurchlässigkeit steht in Verbindung mit Stuhlhäufigkeit beim Durchfall-prädomonaten Reizdarmsyndrom

Gecse, K., Róka, R., Séra, T., Rosztóczy, A., Annaházi, A., Izbéki, F., Nagy, F., Molnár, T., Szepes, Z., Pávics, L., Bueno, L., & Wittmann, T. (2012). Leaky gut in patients with diarrhea-predominant irritable bowel syndrome and inactive ulcerative colitis. Digestion, 85(1), 40–46. https://doi.org/10.1159/000333083

22

Erhöhte Darmwanddurchlässigkeit und Schmerzempfindlichkeit beim Durchfall-prädomonaten Reizdarmsyndrom

Zhou, Q., Zhang, B., & Verne, G. N. (2009). Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome. Pain, 146(1-2), 41–46. https://doi.org/10.1016/j.pain.2009.06.017

23

Immunmechanismen von Allergien und die Rolle der regulatorischen T-Zellen

Calzada, D., Baos, S., Cremades-Jimeno, L., & Cárdaba, B. (2018). Immunological Mechanisms in Allergic Diseases and Allergen Tolerance: The Role of Treg Cells. Journal of immunology research, 2018, 6012053. https://doi.org/10.1155/2018/6012053

24

Klinische Studie zur Behandlung des Reizdarmsyndroms mit B. bifidum HI-MIMBb75

Andresen, V., Gschossmann, J., & Layer, P. (2020). Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. The lancet. Gastroenterology & hepatology, 5(7), 658–666. https://doi.org/10.1016/S2468-1253(20)30056-X

25

Klinische Studie zur Behandlung des Reizdarmsyndroms mit B. bifidum MIMBb75 (lebender Stamm)

Guglielmetti, S., Mora, D., Gschwender, M., & Popp, K. (2011). Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study. Alimentary pharmacology & therapeutics, 33(10), 1123–1132. https://doi.org/10.1111/j.1365-2036.2011.04633.x

26

Laktobazillen in der Behandlung von allergischer Rhinitis

Steiner, N. C., & Lorentz, A. (2021). Probiotic Potential of Lactobacillus Species in Allergic Rhinitis. International archives of allergy and immunology, 182(9), 807–818. https://doi.org/10.1159/000515352

27

Messen von Darmwanddurchlässigkeit mit moderner transkutaner Floureszenzspektroskopie

Gan, J., Monfort Sánchez, E., Avery, J., Barbouti, O., Hoare, J., Ashrafian, H., Darzi, A., & Thompson, A. J. (2022). Non-invasive assessment of intestinal permeability in healthy volunteers using transcutaneous fluorescence spectroscopy. Methods and applications in fluorescence, 10(4), 10.1088/2050-6120/ac9513. https://doi.org/10.1088/2050-6120/ac9513

28

Probiotika

Kim, S. K., Guevarra, R. B., Kim, Y. T., Kwon, J., Kim, H., Cho, J. H., Kim, H. B., & Lee, J. H. (2019). Role of Probiotics in Human Gut Microbiome-Associated Diseases. Journal of microbiology and biotechnology, 29(9), 1335–1340. https://doi.org/10.4014/jmb.1906.06064

29

Probiotika in der Behandlung von allergischer Rhinitis

Luo, C., Peng, S., Li, M., Ao, X., & Liu, Z. (2022). The Efficacy and Safety of Probiotics for Allergic Rhinitis: A Systematic Review and Meta-Analysis. Frontiers in immunology, 13, 848279. https://doi.org/10.3389/fimmu.2022.848279

30

Probiotika modulieren Immunreaktionen in allergischen Erkrankungen

Eslami, M., Bahar, A., Keikha, M., Karbalaei, M., Kobyliak, N. M., & Yousefi, B. (2020). Probiotics function and modulation of the immune system in allergic diseases. Allergologia et immunopathologia, 48(6), 771–788. https://doi.org/10.1016/j.aller.2020.04.005

31

Sichtbare Lücken in der Darmbarriere beim Reizdarmsyndrom festgestellt mit konfokaler Laser-Endomikroskopie

Turcotte, J. F., Kao, D., Mah, S. J., Claggett, B., Saltzman, J. R., Fedorak, R. N., & Liu, J. J. (2013). Breaks in the wall: increased gaps in the intestinal epithelium of irritable bowel syndrome patients identified by confocal laser endomicroscopy (with videos). Gastrointestinal endoscopy, 77(4), 624–630. https://doi.org/10.1016/j.gie.2012.11.006

32

Sichtbare strukturelle Veränderungen der Darmbarriere im Durchfall-prädominaten Reizdarmsyndrom

Martínez, C., Lobo, B., Pigrau, M., Ramos, L., González-Castro, A. M., Alonso, C., Guilarte, M., Guilá, M., de Torres, I., Azpiroz, F., Santos, J., & Vicario, M. (2013). Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier. Gut, 62(8), 1160–1168. https://doi.org/10.1136/gutjnl-2012-302093

33

Stoffwechselprodukte von Darmbakterien modulieren Treg-Zellen

Calvo-Barreiro, L., Zhang, L., Abdel-Rahman, S. A., Naik, S. P., & Gabr, M. (2023). Gut Microbial-Derived Metabolites as Immune Modulators of T Helper 17 and Regulatory T Cells. International journal of molecular sciences, 24(2), 1806. https://doi.org/10.3390/ijms24021806

34

Strukturelle Veränderungen der Darmbarriere stehen in Verbindung mit Symptomeschwere beim RDS-Subtyp alternierende Symptome

Wilcz-Villega, E., McClean, S., & O'Sullivan, M. (2014). Reduced E-cadherin expression is associated with abdominal pain and symptom duration in a study of alternating and diarrhea predominant IBS. Neurogastroenterology and motility, 26(3), 316–325. https://doi.org/10.1111/nmo.12262

35

Studie II zur Adhesionsfähigkeit von B. bifidum MIMBb75 an Darmzellen

Guglielmetti, S., Tamagnini, I., Minuzzo, M., Arioli, S., Parini, C., Comelli, E., & Mora, D. (2009). Study of the adhesion of Bifidobacterium bifidum MIMBb75 to human intestinal cell lines. Current microbiology, 59(2), 167–172. https://doi.org/10.1007/s00284-009-9415-x

36

Studie zur Adhesionsfähigkeit von B. bifidum MIMBb75 an Darmzellen

Guglielmetti, S., Tamagnini, I., Mora, D., Minuzzo, M., Scarafoni, A., Arioli, S., Hellman, J., Karp, M., & Parini, C. (2008). Implication of an outer surface lipoprotein in adhesion of Bifidobacterium bifidum to Caco-2 cells. Applied and environmental microbiology, 74(15), 4695–4702. https://doi.org/10.1128/AEM.00124-08

37

Techniken und Biomarker um Darmdurchlässigkeit non-invasiv zu messen

Perez-Diaz-Del-Campo, N., Castelnuovo, G., Ribaldone, D. G., & Caviglia, G. P. (2023). Fecal and Circulating Biomarkers for the Non-Invasive Assessment of Intestinal Permeability. Diagnostics (Basel, Switzerland), 13(11), 1976. https://doi.org/10.3390/diagnostics13111976

38

Verbindung zwischen Darmbakterien und allergischen Erkrankungen

Han, P., Gu, J. Q., Li, L. S., Wang, X. Y., Wang, H. T., Wang, Y., Chang, C., & Sun, J. L. (2021). The Association Between Intestinal Bacteria and Allergic Diseases-Cause or Consequence?. Frontiers in cellular and infection microbiology, 11, 650893. https://doi.org/10.3389/fcimb.2021.650893

39

Veränderungen des Darmmikrobioms bei Kindern mit allergischen Atemwegserkrankungen

Wan, J., Song, J., Lv, Q., Zhang, H., Xiang, Q., Dai, H., Zheng, H., Lin, X., & Zhang, W. (2023). Alterations in the Gut Microbiome of Young Children with Airway Allergic Disease Revealed by Next-Generation Sequencing. Journal of asthma and allergy, 16, 961–972. https://doi.org/10.2147/JAA.S422537

40

Zerstörung der Darmbarriere durch erhöhte Aktivität von Enzymen verursacht Symptome in RDS-C

Annaházi, A., Ferrier, L., Bézirard, V., Lévêque, M., Eutamène, H., Ait-Belgnaoui, A., Coëffier, M., Ducrotté, P., Róka, R., Inczefi, O., Gecse, K., Rosztóczy, A., Molnár, T., Ringel-Kulka, T., Ringel, Y., Piche, T., Theodorou, V., Wittmann, T., & Bueno, L. (2013). Luminal cysteine-proteases degrade colonic tight junction structure and are responsible for abdominal pain in constipation-predominant IBS. The American journal of gastroenterology, 108(8), 1322–1331. https://doi.org/10.1038/ajg.2013.152

1

Aktuelle Methoden um Darmdurchlässigkeit zu messen

Schoultz, I., & Keita, Å. V. (2020). The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability. Cells, 9(8), 1909. https://doi.org/10.3390/cells9081909

2

American Gut Project zeigt Verbindung zwischen Allergien bei Erwachsenen und Darmmikrobiom

Hua, X., Goedert, J. J., Pu, A., Yu, G., & Shi, J. (2015). Allergy associations with the adult fecal microbiota: Analysis of the American Gut Project. EBioMedicine, 3, 172–179. https://doi.org/10.1016/j.ebiom.2015.11.038

3

Bedeutung von regulatorische T-Zellen für Allergietherapien

Palomares, O., Akdis, M., Martín-Fontecha, M., & Akdis, C. A. (2017). Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells. Immunological reviews, 278(1), 219–236. https://doi.org/10.1111/imr.12555

4

Darmdurchlässigkeit in Darmerkrankungen und Methoden um sie zu bestimmen

Vanuytsel, T., Tack, J., & Farre, R. (2021). The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation. Frontiers in nutrition, 8, 717925. https://doi.org/10.3389/fnut.2021.717925

5

Darmmikrobiom und verschiedene Erkrankungen

Afzaal, M., Saeed, F., Shah, Y. A., Hussain, M., Rabail, R., Socol, C. T., Hassoun, A., Pateiro, M., Lorenzo, J. M., Rusu, A. V., & Aadil, R. M. (2022). Human gut microbiota in health and disease: Unveiling the relationship. Frontiers in microbiology, 13, 999001. https://doi.org/10.3389/fmicb.2022.999001

6

Darmmikrobiomsignaturen von Kindern mit allergischer Rhinitis

Zhang, P., Zhou, X., Tan, H., Jian, F., Jing, Z., Wu, H., Zhang, Y., Luo, J., Zhang, J., & Sun, X. (2023). Microbial signature of intestine in children with allergic rhinitis. Frontiers in microbiology, 14, 1208816. https://doi.org/10.3389/fmicb.2023.1208816

7

Das Darmmikrobiom in allergischer Rhinits unterscheidet sich von anderen allergischen Erkrankungen

Su, Y. J., Luo, S. D., Hsu, C. Y., & Kuo, H. C. (2021). Differences in gut microbiota between allergic rhinitis, atopic dermatitis, and skin urticaria: A pilot study. Medicine, 100(9), e25091. https://doi.org/10.1097/MD.0000000000025091

8

Das Darmmikrobiom von Erwachsenen mit allergischer Rhinits ist weniger divers und hat eine reduzierte Vielfalt von Schlüsselbakterien

Watts, A. M., West, N. P., Zhang, P., Smith, P. K., Cripps, A. W., & Cox, A. J. (2021). The Gut Microbiome of Adults with Allergic Rhinitis Is Characterised by Reduced Diversity and an Altered Abundance of Key Microbial Taxa Compared to Controls. International archives of allergy and immunology, 182(2), 94–105. https://doi.org/10.1159/000510536

9

Der Effekt des Darmmikrobioms und Probiotika auf Gewicht und Fettleibigkeit

Aoun, A., Darwish, F., & Hamod, N. (2020). The Influence of the Gut Microbiome on Obesity in Adults and the Role of Probiotics, Prebiotics, and Synbiotics for Weight Loss. Preventive nutrition and food science, 25(2), 113–123. https://doi.org/10.3746/pnf.2020.25.2.113

10

Der Einfluss von Rauchen auf das Mikrobiom

Shapiro, H., Goldenberg, K., Ratiner, K., & Elinav, E. (2022). Smoking-induced microbial dysbiosis in health and disease. Clinical science (London, England : 1979), 136(18), 1371–1387. https://doi.org/10.1042/CS20220175

11

Der Zusammenhang von erhöhter Darmpermeabilität, Entzündung und Schmerzen beim Reizdarmsyndrom

Camilleri, M., Lasch, K., & Zhou, W. (2012). Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome. American journal of physiology. Gastrointestinal and liver physiology, 303(7), G775–G785. https://doi.org/10.1152/ajpgi.00155.2012

12

Die Adhäsion von B. bifidum MIMBb75 an Darmzellen wird nicht durch das bakterielle Oberflächenprotein BopA bestimmt, sondern beruht auf hydrophober Anziehung

Kainulainen, V., Reunanen, J., Hiippala, K., Guglielmetti, S., Vesterlund, S., Palva, A., & Satokari, R. (2013). BopA does not have a major role in the adhesion of Bifidobacterium bifidum to intestinal epithelial cells, extracellular matrix proteins, and mucus. Applied and environmental microbiology, 79(22), 6989–6997. https://doi.org/10.1128/AEM.01993-13

13

Die Adhäsion von Bifidobakterien an Darmgewebe

Westermann, C., Gleinser, M., Corr, S. C., & Riedel, C. U. (2016). A Critical Evaluation of Bifidobacterial Adhesion to the Host Tissue. Frontiers in microbiology, 7, 1220. https://doi.org/10.3389/fmicb.2016.01220

14

Die Rolle von regulatorischen T-Zellen in Allergien

Pellerin, L., Jenks, J. A., Bégin, P., Bacchetta, R., & Nadeau, K. C. (2014). Regulatory T cells and their roles in immune dysregulation and allergy. Immunologic research, 58(2-3), 358–368. https://doi.org/10.1007/s12026-014-8512-5

15

Die Rolle von regulatorischen T-Zellen in Allergien

Noval Rivas, M., & Chatila, T. A. (2016). Regulatory T cells in allergic diseases. The Journal of allergy and clinical immunology, 138(3), 639–652. https://doi.org/10.1016/j.jaci.2016.06.003

16

Dysbiose verursacht allergische Immunantworten

Augustine, T., Kumar, M., Al Khodor, S., & van Panhuys, N. (2023). Microbial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes. Clinical reviews in allergy & immunology, 65(1), 43–71. https://doi.org/10.1007/s12016-022-08939-9

17

Dysbiose verursacht nachhältige Veränderungen der Treg-Zellen im Körper

Zhang, X., Borbet, T. C., Fallegger, A., Wipperman, M. F., Blaser, M. J., & Müller, A. (2021). An Antibiotic-Impacted Microbiota Compromises the Development of Colonic Regulatory T Cells and Predisposes to Dysregulated Immune Responses. mBio, 12(1), e03335-20. https://doi.org/10.1128/mBio.03335-20

18

Effektivität und Sicherheit von Mikrobiomsupplementation in der Behandlung von allergischer Rhinitis

Liu, D., Wang, X., & Zhang, H. (2023). Efficacy and safety of gastrointestinal microbiome supplementation for allergic rhinitis: A systematic review and meta-analysis with trial sequential analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology, 118, 154948. https://doi.org/10.1016/j.phymed.2023.154948

19

Effektivität von Probiotika in der Behandlung von Kindern mit allergischer Rhinits

Wang, X., Tan, X., & Zhou, J. (2022). Effectiveness and safety of probiotic therapy for pediatric allergic rhinitis management: A systematic review and meta-analysis. International journal of pediatric otorhinolaryngology, 162, 111300. https://doi.org/10.1016/j.ijporl.2022.111300

20

Eigenschaften des Darmmikrobioms von Erwachsenen mit allergischer Rhinits

Zhu, L., Xu, F., Wan, W., Yu, B., Tang, L., Yang, Y., Du, Y., Chen, Z., & Xu, H. (2020). Gut microbial characteristics of adult patients with allergy rhinitis. Microbial cell factories, 19(1), 171. https://doi.org/10.1186/s12934-020-01430-0

21

Erhöhte Darmwanddurchlässigkeit steht in Verbindung mit Stuhlhäufigkeit beim Durchfall-prädomonaten Reizdarmsyndrom

Gecse, K., Róka, R., Séra, T., Rosztóczy, A., Annaházi, A., Izbéki, F., Nagy, F., Molnár, T., Szepes, Z., Pávics, L., Bueno, L., & Wittmann, T. (2012). Leaky gut in patients with diarrhea-predominant irritable bowel syndrome and inactive ulcerative colitis. Digestion, 85(1), 40–46. https://doi.org/10.1159/000333083

22

Erhöhte Darmwanddurchlässigkeit und Schmerzempfindlichkeit beim Durchfall-prädomonaten Reizdarmsyndrom

Zhou, Q., Zhang, B., & Verne, G. N. (2009). Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome. Pain, 146(1-2), 41–46. https://doi.org/10.1016/j.pain.2009.06.017

23

Immunmechanismen von Allergien und die Rolle der regulatorischen T-Zellen

Calzada, D., Baos, S., Cremades-Jimeno, L., & Cárdaba, B. (2018). Immunological Mechanisms in Allergic Diseases and Allergen Tolerance: The Role of Treg Cells. Journal of immunology research, 2018, 6012053. https://doi.org/10.1155/2018/6012053

24

Klinische Studie zur Behandlung des Reizdarmsyndroms mit B. bifidum HI-MIMBb75

Andresen, V., Gschossmann, J., & Layer, P. (2020). Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. The lancet. Gastroenterology & hepatology, 5(7), 658–666. https://doi.org/10.1016/S2468-1253(20)30056-X

25

Klinische Studie zur Behandlung des Reizdarmsyndroms mit B. bifidum MIMBb75 (lebender Stamm)

Guglielmetti, S., Mora, D., Gschwender, M., & Popp, K. (2011). Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study. Alimentary pharmacology & therapeutics, 33(10), 1123–1132. https://doi.org/10.1111/j.1365-2036.2011.04633.x

26

Laktobazillen in der Behandlung von allergischer Rhinitis

Steiner, N. C., & Lorentz, A. (2021). Probiotic Potential of Lactobacillus Species in Allergic Rhinitis. International archives of allergy and immunology, 182(9), 807–818. https://doi.org/10.1159/000515352

27

Messen von Darmwanddurchlässigkeit mit moderner transkutaner Floureszenzspektroskopie

Gan, J., Monfort Sánchez, E., Avery, J., Barbouti, O., Hoare, J., Ashrafian, H., Darzi, A., & Thompson, A. J. (2022). Non-invasive assessment of intestinal permeability in healthy volunteers using transcutaneous fluorescence spectroscopy. Methods and applications in fluorescence, 10(4), 10.1088/2050-6120/ac9513. https://doi.org/10.1088/2050-6120/ac9513

28

Probiotika

Kim, S. K., Guevarra, R. B., Kim, Y. T., Kwon, J., Kim, H., Cho, J. H., Kim, H. B., & Lee, J. H. (2019). Role of Probiotics in Human Gut Microbiome-Associated Diseases. Journal of microbiology and biotechnology, 29(9), 1335–1340. https://doi.org/10.4014/jmb.1906.06064

29

Probiotika in der Behandlung von allergischer Rhinitis

Luo, C., Peng, S., Li, M., Ao, X., & Liu, Z. (2022). The Efficacy and Safety of Probiotics for Allergic Rhinitis: A Systematic Review and Meta-Analysis. Frontiers in immunology, 13, 848279. https://doi.org/10.3389/fimmu.2022.848279

30

Probiotika modulieren Immunreaktionen in allergischen Erkrankungen

Eslami, M., Bahar, A., Keikha, M., Karbalaei, M., Kobyliak, N. M., & Yousefi, B. (2020). Probiotics function and modulation of the immune system in allergic diseases. Allergologia et immunopathologia, 48(6), 771–788. https://doi.org/10.1016/j.aller.2020.04.005

31

Sichtbare Lücken in der Darmbarriere beim Reizdarmsyndrom festgestellt mit konfokaler Laser-Endomikroskopie

Turcotte, J. F., Kao, D., Mah, S. J., Claggett, B., Saltzman, J. R., Fedorak, R. N., & Liu, J. J. (2013). Breaks in the wall: increased gaps in the intestinal epithelium of irritable bowel syndrome patients identified by confocal laser endomicroscopy (with videos). Gastrointestinal endoscopy, 77(4), 624–630. https://doi.org/10.1016/j.gie.2012.11.006

32

Sichtbare strukturelle Veränderungen der Darmbarriere im Durchfall-prädominaten Reizdarmsyndrom

Martínez, C., Lobo, B., Pigrau, M., Ramos, L., González-Castro, A. M., Alonso, C., Guilarte, M., Guilá, M., de Torres, I., Azpiroz, F., Santos, J., & Vicario, M. (2013). Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier. Gut, 62(8), 1160–1168. https://doi.org/10.1136/gutjnl-2012-302093

33

Stoffwechselprodukte von Darmbakterien modulieren Treg-Zellen

Calvo-Barreiro, L., Zhang, L., Abdel-Rahman, S. A., Naik, S. P., & Gabr, M. (2023). Gut Microbial-Derived Metabolites as Immune Modulators of T Helper 17 and Regulatory T Cells. International journal of molecular sciences, 24(2), 1806. https://doi.org/10.3390/ijms24021806

34

Strukturelle Veränderungen der Darmbarriere stehen in Verbindung mit Symptomeschwere beim RDS-Subtyp alternierende Symptome

Wilcz-Villega, E., McClean, S., & O'Sullivan, M. (2014). Reduced E-cadherin expression is associated with abdominal pain and symptom duration in a study of alternating and diarrhea predominant IBS. Neurogastroenterology and motility, 26(3), 316–325. https://doi.org/10.1111/nmo.12262

35

Studie II zur Adhesionsfähigkeit von B. bifidum MIMBb75 an Darmzellen

Guglielmetti, S., Tamagnini, I., Minuzzo, M., Arioli, S., Parini, C., Comelli, E., & Mora, D. (2009). Study of the adhesion of Bifidobacterium bifidum MIMBb75 to human intestinal cell lines. Current microbiology, 59(2), 167–172. https://doi.org/10.1007/s00284-009-9415-x

36

Studie zur Adhesionsfähigkeit von B. bifidum MIMBb75 an Darmzellen

Guglielmetti, S., Tamagnini, I., Mora, D., Minuzzo, M., Scarafoni, A., Arioli, S., Hellman, J., Karp, M., & Parini, C. (2008). Implication of an outer surface lipoprotein in adhesion of Bifidobacterium bifidum to Caco-2 cells. Applied and environmental microbiology, 74(15), 4695–4702. https://doi.org/10.1128/AEM.00124-08

37

Techniken und Biomarker um Darmdurchlässigkeit non-invasiv zu messen

Perez-Diaz-Del-Campo, N., Castelnuovo, G., Ribaldone, D. G., & Caviglia, G. P. (2023). Fecal and Circulating Biomarkers for the Non-Invasive Assessment of Intestinal Permeability. Diagnostics (Basel, Switzerland), 13(11), 1976. https://doi.org/10.3390/diagnostics13111976

38

Verbindung zwischen Darmbakterien und allergischen Erkrankungen

Han, P., Gu, J. Q., Li, L. S., Wang, X. Y., Wang, H. T., Wang, Y., Chang, C., & Sun, J. L. (2021). The Association Between Intestinal Bacteria and Allergic Diseases-Cause or Consequence?. Frontiers in cellular and infection microbiology, 11, 650893. https://doi.org/10.3389/fcimb.2021.650893

39

Veränderungen des Darmmikrobioms bei Kindern mit allergischen Atemwegserkrankungen

Wan, J., Song, J., Lv, Q., Zhang, H., Xiang, Q., Dai, H., Zheng, H., Lin, X., & Zhang, W. (2023). Alterations in the Gut Microbiome of Young Children with Airway Allergic Disease Revealed by Next-Generation Sequencing. Journal of asthma and allergy, 16, 961–972. https://doi.org/10.2147/JAA.S422537

40

Zerstörung der Darmbarriere durch erhöhte Aktivität von Enzymen verursacht Symptome in RDS-C

Annaházi, A., Ferrier, L., Bézirard, V., Lévêque, M., Eutamène, H., Ait-Belgnaoui, A., Coëffier, M., Ducrotté, P., Róka, R., Inczefi, O., Gecse, K., Rosztóczy, A., Molnár, T., Ringel-Kulka, T., Ringel, Y., Piche, T., Theodorou, V., Wittmann, T., & Bueno, L. (2013). Luminal cysteine-proteases degrade colonic tight junction structure and are responsible for abdominal pain in constipation-predominant IBS. The American journal of gastroenterology, 108(8), 1322–1331. https://doi.org/10.1038/ajg.2013.152

1

Aktuelle Methoden um Darmdurchlässigkeit zu messen

Schoultz, I., & Keita, Å. V. (2020). The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability. Cells, 9(8), 1909. https://doi.org/10.3390/cells9081909

2

American Gut Project zeigt Verbindung zwischen Allergien bei Erwachsenen und Darmmikrobiom

Hua, X., Goedert, J. J., Pu, A., Yu, G., & Shi, J. (2015). Allergy associations with the adult fecal microbiota: Analysis of the American Gut Project. EBioMedicine, 3, 172–179. https://doi.org/10.1016/j.ebiom.2015.11.038

3

Bedeutung von regulatorische T-Zellen für Allergietherapien

Palomares, O., Akdis, M., Martín-Fontecha, M., & Akdis, C. A. (2017). Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells. Immunological reviews, 278(1), 219–236. https://doi.org/10.1111/imr.12555

4

Darmdurchlässigkeit in Darmerkrankungen und Methoden um sie zu bestimmen

Vanuytsel, T., Tack, J., & Farre, R. (2021). The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation. Frontiers in nutrition, 8, 717925. https://doi.org/10.3389/fnut.2021.717925

5

Darmmikrobiom und verschiedene Erkrankungen

Afzaal, M., Saeed, F., Shah, Y. A., Hussain, M., Rabail, R., Socol, C. T., Hassoun, A., Pateiro, M., Lorenzo, J. M., Rusu, A. V., & Aadil, R. M. (2022). Human gut microbiota in health and disease: Unveiling the relationship. Frontiers in microbiology, 13, 999001. https://doi.org/10.3389/fmicb.2022.999001

6

Darmmikrobiomsignaturen von Kindern mit allergischer Rhinitis

Zhang, P., Zhou, X., Tan, H., Jian, F., Jing, Z., Wu, H., Zhang, Y., Luo, J., Zhang, J., & Sun, X. (2023). Microbial signature of intestine in children with allergic rhinitis. Frontiers in microbiology, 14, 1208816. https://doi.org/10.3389/fmicb.2023.1208816

7

Das Darmmikrobiom in allergischer Rhinits unterscheidet sich von anderen allergischen Erkrankungen

Su, Y. J., Luo, S. D., Hsu, C. Y., & Kuo, H. C. (2021). Differences in gut microbiota between allergic rhinitis, atopic dermatitis, and skin urticaria: A pilot study. Medicine, 100(9), e25091. https://doi.org/10.1097/MD.0000000000025091

8

Das Darmmikrobiom von Erwachsenen mit allergischer Rhinits ist weniger divers und hat eine reduzierte Vielfalt von Schlüsselbakterien

Watts, A. M., West, N. P., Zhang, P., Smith, P. K., Cripps, A. W., & Cox, A. J. (2021). The Gut Microbiome of Adults with Allergic Rhinitis Is Characterised by Reduced Diversity and an Altered Abundance of Key Microbial Taxa Compared to Controls. International archives of allergy and immunology, 182(2), 94–105. https://doi.org/10.1159/000510536

9

Der Effekt des Darmmikrobioms und Probiotika auf Gewicht und Fettleibigkeit

Aoun, A., Darwish, F., & Hamod, N. (2020). The Influence of the Gut Microbiome on Obesity in Adults and the Role of Probiotics, Prebiotics, and Synbiotics for Weight Loss. Preventive nutrition and food science, 25(2), 113–123. https://doi.org/10.3746/pnf.2020.25.2.113

10

Der Einfluss von Rauchen auf das Mikrobiom

Shapiro, H., Goldenberg, K., Ratiner, K., & Elinav, E. (2022). Smoking-induced microbial dysbiosis in health and disease. Clinical science (London, England : 1979), 136(18), 1371–1387. https://doi.org/10.1042/CS20220175

11

Der Zusammenhang von erhöhter Darmpermeabilität, Entzündung und Schmerzen beim Reizdarmsyndrom

Camilleri, M., Lasch, K., & Zhou, W. (2012). Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome. American journal of physiology. Gastrointestinal and liver physiology, 303(7), G775–G785. https://doi.org/10.1152/ajpgi.00155.2012

12

Die Adhäsion von B. bifidum MIMBb75 an Darmzellen wird nicht durch das bakterielle Oberflächenprotein BopA bestimmt, sondern beruht auf hydrophober Anziehung

Kainulainen, V., Reunanen, J., Hiippala, K., Guglielmetti, S., Vesterlund, S., Palva, A., & Satokari, R. (2013). BopA does not have a major role in the adhesion of Bifidobacterium bifidum to intestinal epithelial cells, extracellular matrix proteins, and mucus. Applied and environmental microbiology, 79(22), 6989–6997. https://doi.org/10.1128/AEM.01993-13

13

Die Adhäsion von Bifidobakterien an Darmgewebe

Westermann, C., Gleinser, M., Corr, S. C., & Riedel, C. U. (2016). A Critical Evaluation of Bifidobacterial Adhesion to the Host Tissue. Frontiers in microbiology, 7, 1220. https://doi.org/10.3389/fmicb.2016.01220

14

Die Rolle von regulatorischen T-Zellen in Allergien

Pellerin, L., Jenks, J. A., Bégin, P., Bacchetta, R., & Nadeau, K. C. (2014). Regulatory T cells and their roles in immune dysregulation and allergy. Immunologic research, 58(2-3), 358–368. https://doi.org/10.1007/s12026-014-8512-5

15

Die Rolle von regulatorischen T-Zellen in Allergien

Noval Rivas, M., & Chatila, T. A. (2016). Regulatory T cells in allergic diseases. The Journal of allergy and clinical immunology, 138(3), 639–652. https://doi.org/10.1016/j.jaci.2016.06.003

16

Dysbiose verursacht allergische Immunantworten

Augustine, T., Kumar, M., Al Khodor, S., & van Panhuys, N. (2023). Microbial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes. Clinical reviews in allergy & immunology, 65(1), 43–71. https://doi.org/10.1007/s12016-022-08939-9

17

Dysbiose verursacht nachhältige Veränderungen der Treg-Zellen im Körper

Zhang, X., Borbet, T. C., Fallegger, A., Wipperman, M. F., Blaser, M. J., & Müller, A. (2021). An Antibiotic-Impacted Microbiota Compromises the Development of Colonic Regulatory T Cells and Predisposes to Dysregulated Immune Responses. mBio, 12(1), e03335-20. https://doi.org/10.1128/mBio.03335-20

18

Effektivität und Sicherheit von Mikrobiomsupplementation in der Behandlung von allergischer Rhinitis

Liu, D., Wang, X., & Zhang, H. (2023). Efficacy and safety of gastrointestinal microbiome supplementation for allergic rhinitis: A systematic review and meta-analysis with trial sequential analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology, 118, 154948. https://doi.org/10.1016/j.phymed.2023.154948

19

Effektivität von Probiotika in der Behandlung von Kindern mit allergischer Rhinits

Wang, X., Tan, X., & Zhou, J. (2022). Effectiveness and safety of probiotic therapy for pediatric allergic rhinitis management: A systematic review and meta-analysis. International journal of pediatric otorhinolaryngology, 162, 111300. https://doi.org/10.1016/j.ijporl.2022.111300

20

Eigenschaften des Darmmikrobioms von Erwachsenen mit allergischer Rhinits

Zhu, L., Xu, F., Wan, W., Yu, B., Tang, L., Yang, Y., Du, Y., Chen, Z., & Xu, H. (2020). Gut microbial characteristics of adult patients with allergy rhinitis. Microbial cell factories, 19(1), 171. https://doi.org/10.1186/s12934-020-01430-0

21

Erhöhte Darmwanddurchlässigkeit steht in Verbindung mit Stuhlhäufigkeit beim Durchfall-prädomonaten Reizdarmsyndrom

Gecse, K., Róka, R., Séra, T., Rosztóczy, A., Annaházi, A., Izbéki, F., Nagy, F., Molnár, T., Szepes, Z., Pávics, L., Bueno, L., & Wittmann, T. (2012). Leaky gut in patients with diarrhea-predominant irritable bowel syndrome and inactive ulcerative colitis. Digestion, 85(1), 40–46. https://doi.org/10.1159/000333083

22

Erhöhte Darmwanddurchlässigkeit und Schmerzempfindlichkeit beim Durchfall-prädomonaten Reizdarmsyndrom

Zhou, Q., Zhang, B., & Verne, G. N. (2009). Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome. Pain, 146(1-2), 41–46. https://doi.org/10.1016/j.pain.2009.06.017

23

Immunmechanismen von Allergien und die Rolle der regulatorischen T-Zellen

Calzada, D., Baos, S., Cremades-Jimeno, L., & Cárdaba, B. (2018). Immunological Mechanisms in Allergic Diseases and Allergen Tolerance: The Role of Treg Cells. Journal of immunology research, 2018, 6012053. https://doi.org/10.1155/2018/6012053

24

Klinische Studie zur Behandlung des Reizdarmsyndroms mit B. bifidum HI-MIMBb75

Andresen, V., Gschossmann, J., & Layer, P. (2020). Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. The lancet. Gastroenterology & hepatology, 5(7), 658–666. https://doi.org/10.1016/S2468-1253(20)30056-X

25

Klinische Studie zur Behandlung des Reizdarmsyndroms mit B. bifidum MIMBb75 (lebender Stamm)

Guglielmetti, S., Mora, D., Gschwender, M., & Popp, K. (2011). Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study. Alimentary pharmacology & therapeutics, 33(10), 1123–1132. https://doi.org/10.1111/j.1365-2036.2011.04633.x

26

Laktobazillen in der Behandlung von allergischer Rhinitis

Steiner, N. C., & Lorentz, A. (2021). Probiotic Potential of Lactobacillus Species in Allergic Rhinitis. International archives of allergy and immunology, 182(9), 807–818. https://doi.org/10.1159/000515352

27

Messen von Darmwanddurchlässigkeit mit moderner transkutaner Floureszenzspektroskopie

Gan, J., Monfort Sánchez, E., Avery, J., Barbouti, O., Hoare, J., Ashrafian, H., Darzi, A., & Thompson, A. J. (2022). Non-invasive assessment of intestinal permeability in healthy volunteers using transcutaneous fluorescence spectroscopy. Methods and applications in fluorescence, 10(4), 10.1088/2050-6120/ac9513. https://doi.org/10.1088/2050-6120/ac9513

28

Probiotika

Kim, S. K., Guevarra, R. B., Kim, Y. T., Kwon, J., Kim, H., Cho, J. H., Kim, H. B., & Lee, J. H. (2019). Role of Probiotics in Human Gut Microbiome-Associated Diseases. Journal of microbiology and biotechnology, 29(9), 1335–1340. https://doi.org/10.4014/jmb.1906.06064

29

Probiotika in der Behandlung von allergischer Rhinitis

Luo, C., Peng, S., Li, M., Ao, X., & Liu, Z. (2022). The Efficacy and Safety of Probiotics for Allergic Rhinitis: A Systematic Review and Meta-Analysis. Frontiers in immunology, 13, 848279. https://doi.org/10.3389/fimmu.2022.848279

30

Probiotika modulieren Immunreaktionen in allergischen Erkrankungen

Eslami, M., Bahar, A., Keikha, M., Karbalaei, M., Kobyliak, N. M., & Yousefi, B. (2020). Probiotics function and modulation of the immune system in allergic diseases. Allergologia et immunopathologia, 48(6), 771–788. https://doi.org/10.1016/j.aller.2020.04.005

31

Sichtbare Lücken in der Darmbarriere beim Reizdarmsyndrom festgestellt mit konfokaler Laser-Endomikroskopie

Turcotte, J. F., Kao, D., Mah, S. J., Claggett, B., Saltzman, J. R., Fedorak, R. N., & Liu, J. J. (2013). Breaks in the wall: increased gaps in the intestinal epithelium of irritable bowel syndrome patients identified by confocal laser endomicroscopy (with videos). Gastrointestinal endoscopy, 77(4), 624–630. https://doi.org/10.1016/j.gie.2012.11.006

32

Sichtbare strukturelle Veränderungen der Darmbarriere im Durchfall-prädominaten Reizdarmsyndrom

Martínez, C., Lobo, B., Pigrau, M., Ramos, L., González-Castro, A. M., Alonso, C., Guilarte, M., Guilá, M., de Torres, I., Azpiroz, F., Santos, J., & Vicario, M. (2013). Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier. Gut, 62(8), 1160–1168. https://doi.org/10.1136/gutjnl-2012-302093

33

Stoffwechselprodukte von Darmbakterien modulieren Treg-Zellen

Calvo-Barreiro, L., Zhang, L., Abdel-Rahman, S. A., Naik, S. P., & Gabr, M. (2023). Gut Microbial-Derived Metabolites as Immune Modulators of T Helper 17 and Regulatory T Cells. International journal of molecular sciences, 24(2), 1806. https://doi.org/10.3390/ijms24021806

34

Strukturelle Veränderungen der Darmbarriere stehen in Verbindung mit Symptomeschwere beim RDS-Subtyp alternierende Symptome

Wilcz-Villega, E., McClean, S., & O'Sullivan, M. (2014). Reduced E-cadherin expression is associated with abdominal pain and symptom duration in a study of alternating and diarrhea predominant IBS. Neurogastroenterology and motility, 26(3), 316–325. https://doi.org/10.1111/nmo.12262

35

Studie II zur Adhesionsfähigkeit von B. bifidum MIMBb75 an Darmzellen

Guglielmetti, S., Tamagnini, I., Minuzzo, M., Arioli, S., Parini, C., Comelli, E., & Mora, D. (2009). Study of the adhesion of Bifidobacterium bifidum MIMBb75 to human intestinal cell lines. Current microbiology, 59(2), 167–172. https://doi.org/10.1007/s00284-009-9415-x

36

Studie zur Adhesionsfähigkeit von B. bifidum MIMBb75 an Darmzellen

Guglielmetti, S., Tamagnini, I., Mora, D., Minuzzo, M., Scarafoni, A., Arioli, S., Hellman, J., Karp, M., & Parini, C. (2008). Implication of an outer surface lipoprotein in adhesion of Bifidobacterium bifidum to Caco-2 cells. Applied and environmental microbiology, 74(15), 4695–4702. https://doi.org/10.1128/AEM.00124-08

37

Techniken und Biomarker um Darmdurchlässigkeit non-invasiv zu messen

Perez-Diaz-Del-Campo, N., Castelnuovo, G., Ribaldone, D. G., & Caviglia, G. P. (2023). Fecal and Circulating Biomarkers for the Non-Invasive Assessment of Intestinal Permeability. Diagnostics (Basel, Switzerland), 13(11), 1976. https://doi.org/10.3390/diagnostics13111976

38

Verbindung zwischen Darmbakterien und allergischen Erkrankungen

Han, P., Gu, J. Q., Li, L. S., Wang, X. Y., Wang, H. T., Wang, Y., Chang, C., & Sun, J. L. (2021). The Association Between Intestinal Bacteria and Allergic Diseases-Cause or Consequence?. Frontiers in cellular and infection microbiology, 11, 650893. https://doi.org/10.3389/fcimb.2021.650893

39

Veränderungen des Darmmikrobioms bei Kindern mit allergischen Atemwegserkrankungen

Wan, J., Song, J., Lv, Q., Zhang, H., Xiang, Q., Dai, H., Zheng, H., Lin, X., & Zhang, W. (2023). Alterations in the Gut Microbiome of Young Children with Airway Allergic Disease Revealed by Next-Generation Sequencing. Journal of asthma and allergy, 16, 961–972. https://doi.org/10.2147/JAA.S422537

40

Zerstörung der Darmbarriere durch erhöhte Aktivität von Enzymen verursacht Symptome in RDS-C

Annaházi, A., Ferrier, L., Bézirard, V., Lévêque, M., Eutamène, H., Ait-Belgnaoui, A., Coëffier, M., Ducrotté, P., Róka, R., Inczefi, O., Gecse, K., Rosztóczy, A., Molnár, T., Ringel-Kulka, T., Ringel, Y., Piche, T., Theodorou, V., Wittmann, T., & Bueno, L. (2013). Luminal cysteine-proteases degrade colonic tight junction structure and are responsible for abdominal pain in constipation-predominant IBS. The American journal of gastroenterology, 108(8), 1322–1331. https://doi.org/10.1038/ajg.2013.152

1

Zerstörung der Darmbarriere durch erhöhte Aktivität von Enzymen verursacht Symptome in RDS-C

Annaházi, A., Ferrier, L., Bézirard, V., Lévêque, M., Eutamène, H., Ait-Belgnaoui, A., Coëffier, M., Ducrotté, P., Róka, R., Inczefi, O., Gecse, K., Rosztóczy, A., Molnár, T., Ringel-Kulka, T., Ringel, Y., Piche, T., Theodorou, V., Wittmann, T., & Bueno, L. (2013). Luminal cysteine-proteases degrade colonic tight junction structure and are responsible for abdominal pain in constipation-predominant IBS. The American journal of gastroenterology, 108(8), 1322–1331. https://doi.org/10.1038/ajg.2013.152

2

Veränderungen des Darmmikrobioms bei Kindern mit allergischen Atemwegserkrankungen

Wan, J., Song, J., Lv, Q., Zhang, H., Xiang, Q., Dai, H., Zheng, H., Lin, X., & Zhang, W. (2023). Alterations in the Gut Microbiome of Young Children with Airway Allergic Disease Revealed by Next-Generation Sequencing. Journal of asthma and allergy, 16, 961–972. https://doi.org/10.2147/JAA.S422537

3

Verbindung zwischen Darmbakterien und allergischen Erkrankungen

Han, P., Gu, J. Q., Li, L. S., Wang, X. Y., Wang, H. T., Wang, Y., Chang, C., & Sun, J. L. (2021). The Association Between Intestinal Bacteria and Allergic Diseases-Cause or Consequence?. Frontiers in cellular and infection microbiology, 11, 650893. https://doi.org/10.3389/fcimb.2021.650893

4

Techniken und Biomarker um Darmdurchlässigkeit non-invasiv zu messen

Perez-Diaz-Del-Campo, N., Castelnuovo, G., Ribaldone, D. G., & Caviglia, G. P. (2023). Fecal and Circulating Biomarkers for the Non-Invasive Assessment of Intestinal Permeability. Diagnostics (Basel, Switzerland), 13(11), 1976. https://doi.org/10.3390/diagnostics13111976

5

Studie zur Adhesionsfähigkeit von B. bifidum MIMBb75 an Darmzellen

Guglielmetti, S., Tamagnini, I., Mora, D., Minuzzo, M., Scarafoni, A., Arioli, S., Hellman, J., Karp, M., & Parini, C. (2008). Implication of an outer surface lipoprotein in adhesion of Bifidobacterium bifidum to Caco-2 cells. Applied and environmental microbiology, 74(15), 4695–4702. https://doi.org/10.1128/AEM.00124-08

6

Studie II zur Adhesionsfähigkeit von B. bifidum MIMBb75 an Darmzellen

Guglielmetti, S., Tamagnini, I., Minuzzo, M., Arioli, S., Parini, C., Comelli, E., & Mora, D. (2009). Study of the adhesion of Bifidobacterium bifidum MIMBb75 to human intestinal cell lines. Current microbiology, 59(2), 167–172. https://doi.org/10.1007/s00284-009-9415-x

7

Strukturelle Veränderungen der Darmbarriere stehen in Verbindung mit Symptomeschwere beim RDS-Subtyp alternierende Symptome

Wilcz-Villega, E., McClean, S., & O'Sullivan, M. (2014). Reduced E-cadherin expression is associated with abdominal pain and symptom duration in a study of alternating and diarrhea predominant IBS. Neurogastroenterology and motility, 26(3), 316–325. https://doi.org/10.1111/nmo.12262

8

Stoffwechselprodukte von Darmbakterien modulieren Treg-Zellen

Calvo-Barreiro, L., Zhang, L., Abdel-Rahman, S. A., Naik, S. P., & Gabr, M. (2023). Gut Microbial-Derived Metabolites as Immune Modulators of T Helper 17 and Regulatory T Cells. International journal of molecular sciences, 24(2), 1806. https://doi.org/10.3390/ijms24021806

9

Sichtbare strukturelle Veränderungen der Darmbarriere im Durchfall-prädominaten Reizdarmsyndrom

Martínez, C., Lobo, B., Pigrau, M., Ramos, L., González-Castro, A. M., Alonso, C., Guilarte, M., Guilá, M., de Torres, I., Azpiroz, F., Santos, J., & Vicario, M. (2013). Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier. Gut, 62(8), 1160–1168. https://doi.org/10.1136/gutjnl-2012-302093

10

Sichtbare Lücken in der Darmbarriere beim Reizdarmsyndrom festgestellt mit konfokaler Laser-Endomikroskopie

Turcotte, J. F., Kao, D., Mah, S. J., Claggett, B., Saltzman, J. R., Fedorak, R. N., & Liu, J. J. (2013). Breaks in the wall: increased gaps in the intestinal epithelium of irritable bowel syndrome patients identified by confocal laser endomicroscopy (with videos). Gastrointestinal endoscopy, 77(4), 624–630. https://doi.org/10.1016/j.gie.2012.11.006

11

Probiotika modulieren Immunreaktionen in allergischen Erkrankungen

Eslami, M., Bahar, A., Keikha, M., Karbalaei, M., Kobyliak, N. M., & Yousefi, B. (2020). Probiotics function and modulation of the immune system in allergic diseases. Allergologia et immunopathologia, 48(6), 771–788. https://doi.org/10.1016/j.aller.2020.04.005

12

Probiotika in der Behandlung von allergischer Rhinitis

Luo, C., Peng, S., Li, M., Ao, X., & Liu, Z. (2022). The Efficacy and Safety of Probiotics for Allergic Rhinitis: A Systematic Review and Meta-Analysis. Frontiers in immunology, 13, 848279. https://doi.org/10.3389/fimmu.2022.848279

13

Probiotika

Kim, S. K., Guevarra, R. B., Kim, Y. T., Kwon, J., Kim, H., Cho, J. H., Kim, H. B., & Lee, J. H. (2019). Role of Probiotics in Human Gut Microbiome-Associated Diseases. Journal of microbiology and biotechnology, 29(9), 1335–1340. https://doi.org/10.4014/jmb.1906.06064

14

Messen von Darmwanddurchlässigkeit mit moderner transkutaner Floureszenzspektroskopie

Gan, J., Monfort Sánchez, E., Avery, J., Barbouti, O., Hoare, J., Ashrafian, H., Darzi, A., & Thompson, A. J. (2022). Non-invasive assessment of intestinal permeability in healthy volunteers using transcutaneous fluorescence spectroscopy. Methods and applications in fluorescence, 10(4), 10.1088/2050-6120/ac9513. https://doi.org/10.1088/2050-6120/ac9513

15

Laktobazillen in der Behandlung von allergischer Rhinitis

Steiner, N. C., & Lorentz, A. (2021). Probiotic Potential of Lactobacillus Species in Allergic Rhinitis. International archives of allergy and immunology, 182(9), 807–818. https://doi.org/10.1159/000515352

16

Klinische Studie zur Behandlung des Reizdarmsyndroms mit B. bifidum MIMBb75 (lebender Stamm)

Guglielmetti, S., Mora, D., Gschwender, M., & Popp, K. (2011). Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study. Alimentary pharmacology & therapeutics, 33(10), 1123–1132. https://doi.org/10.1111/j.1365-2036.2011.04633.x

17

Klinische Studie zur Behandlung des Reizdarmsyndroms mit B. bifidum HI-MIMBb75

Andresen, V., Gschossmann, J., & Layer, P. (2020). Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. The lancet. Gastroenterology & hepatology, 5(7), 658–666. https://doi.org/10.1016/S2468-1253(20)30056-X

18

Immunmechanismen von Allergien und die Rolle der regulatorischen T-Zellen

Calzada, D., Baos, S., Cremades-Jimeno, L., & Cárdaba, B. (2018). Immunological Mechanisms in Allergic Diseases and Allergen Tolerance: The Role of Treg Cells. Journal of immunology research, 2018, 6012053. https://doi.org/10.1155/2018/6012053

19

Erhöhte Darmwanddurchlässigkeit und Schmerzempfindlichkeit beim Durchfall-prädomonaten Reizdarmsyndrom

Zhou, Q., Zhang, B., & Verne, G. N. (2009). Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome. Pain, 146(1-2), 41–46. https://doi.org/10.1016/j.pain.2009.06.017

20

Erhöhte Darmwanddurchlässigkeit steht in Verbindung mit Stuhlhäufigkeit beim Durchfall-prädomonaten Reizdarmsyndrom

Gecse, K., Róka, R., Séra, T., Rosztóczy, A., Annaházi, A., Izbéki, F., Nagy, F., Molnár, T., Szepes, Z., Pávics, L., Bueno, L., & Wittmann, T. (2012). Leaky gut in patients with diarrhea-predominant irritable bowel syndrome and inactive ulcerative colitis. Digestion, 85(1), 40–46. https://doi.org/10.1159/000333083

21

Eigenschaften des Darmmikrobioms von Erwachsenen mit allergischer Rhinits

Zhu, L., Xu, F., Wan, W., Yu, B., Tang, L., Yang, Y., Du, Y., Chen, Z., & Xu, H. (2020). Gut microbial characteristics of adult patients with allergy rhinitis. Microbial cell factories, 19(1), 171. https://doi.org/10.1186/s12934-020-01430-0

22

Effektivität von Probiotika in der Behandlung von Kindern mit allergischer Rhinits

Wang, X., Tan, X., & Zhou, J. (2022). Effectiveness and safety of probiotic therapy for pediatric allergic rhinitis management: A systematic review and meta-analysis. International journal of pediatric otorhinolaryngology, 162, 111300. https://doi.org/10.1016/j.ijporl.2022.111300

23

Effektivität und Sicherheit von Mikrobiomsupplementation in der Behandlung von allergischer Rhinitis

Liu, D., Wang, X., & Zhang, H. (2023). Efficacy and safety of gastrointestinal microbiome supplementation for allergic rhinitis: A systematic review and meta-analysis with trial sequential analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology, 118, 154948. https://doi.org/10.1016/j.phymed.2023.154948

24

Dysbiose verursacht nachhältige Veränderungen der Treg-Zellen im Körper

Zhang, X., Borbet, T. C., Fallegger, A., Wipperman, M. F., Blaser, M. J., & Müller, A. (2021). An Antibiotic-Impacted Microbiota Compromises the Development of Colonic Regulatory T Cells and Predisposes to Dysregulated Immune Responses. mBio, 12(1), e03335-20. https://doi.org/10.1128/mBio.03335-20

25

Dysbiose verursacht allergische Immunantworten

Augustine, T., Kumar, M., Al Khodor, S., & van Panhuys, N. (2023). Microbial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes. Clinical reviews in allergy & immunology, 65(1), 43–71. https://doi.org/10.1007/s12016-022-08939-9

26

Die Rolle von regulatorischen T-Zellen in Allergien

Noval Rivas, M., & Chatila, T. A. (2016). Regulatory T cells in allergic diseases. The Journal of allergy and clinical immunology, 138(3), 639–652. https://doi.org/10.1016/j.jaci.2016.06.003

27

Die Rolle von regulatorischen T-Zellen in Allergien

Pellerin, L., Jenks, J. A., Bégin, P., Bacchetta, R., & Nadeau, K. C. (2014). Regulatory T cells and their roles in immune dysregulation and allergy. Immunologic research, 58(2-3), 358–368. https://doi.org/10.1007/s12026-014-8512-5

28

Die Adhäsion von Bifidobakterien an Darmgewebe

Westermann, C., Gleinser, M., Corr, S. C., & Riedel, C. U. (2016). A Critical Evaluation of Bifidobacterial Adhesion to the Host Tissue. Frontiers in microbiology, 7, 1220. https://doi.org/10.3389/fmicb.2016.01220

29

Die Adhäsion von B. bifidum MIMBb75 an Darmzellen wird nicht durch das bakterielle Oberflächenprotein BopA bestimmt, sondern beruht auf hydrophober Anziehung

Kainulainen, V., Reunanen, J., Hiippala, K., Guglielmetti, S., Vesterlund, S., Palva, A., & Satokari, R. (2013). BopA does not have a major role in the adhesion of Bifidobacterium bifidum to intestinal epithelial cells, extracellular matrix proteins, and mucus. Applied and environmental microbiology, 79(22), 6989–6997. https://doi.org/10.1128/AEM.01993-13

30

Der Zusammenhang von erhöhter Darmpermeabilität, Entzündung und Schmerzen beim Reizdarmsyndrom

Camilleri, M., Lasch, K., & Zhou, W. (2012). Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome. American journal of physiology. Gastrointestinal and liver physiology, 303(7), G775–G785. https://doi.org/10.1152/ajpgi.00155.2012

31

Der Einfluss von Rauchen auf das Mikrobiom

Shapiro, H., Goldenberg, K., Ratiner, K., & Elinav, E. (2022). Smoking-induced microbial dysbiosis in health and disease. Clinical science (London, England : 1979), 136(18), 1371–1387. https://doi.org/10.1042/CS20220175

32

Der Effekt des Darmmikrobioms und Probiotika auf Gewicht und Fettleibigkeit

Aoun, A., Darwish, F., & Hamod, N. (2020). The Influence of the Gut Microbiome on Obesity in Adults and the Role of Probiotics, Prebiotics, and Synbiotics for Weight Loss. Preventive nutrition and food science, 25(2), 113–123. https://doi.org/10.3746/pnf.2020.25.2.113

33

Das Darmmikrobiom von Erwachsenen mit allergischer Rhinits ist weniger divers und hat eine reduzierte Vielfalt von Schlüsselbakterien

Watts, A. M., West, N. P., Zhang, P., Smith, P. K., Cripps, A. W., & Cox, A. J. (2021). The Gut Microbiome of Adults with Allergic Rhinitis Is Characterised by Reduced Diversity and an Altered Abundance of Key Microbial Taxa Compared to Controls. International archives of allergy and immunology, 182(2), 94–105. https://doi.org/10.1159/000510536

34

Das Darmmikrobiom in allergischer Rhinits unterscheidet sich von anderen allergischen Erkrankungen

Su, Y. J., Luo, S. D., Hsu, C. Y., & Kuo, H. C. (2021). Differences in gut microbiota between allergic rhinitis, atopic dermatitis, and skin urticaria: A pilot study. Medicine, 100(9), e25091. https://doi.org/10.1097/MD.0000000000025091

35

Darmmikrobiomsignaturen von Kindern mit allergischer Rhinitis

Zhang, P., Zhou, X., Tan, H., Jian, F., Jing, Z., Wu, H., Zhang, Y., Luo, J., Zhang, J., & Sun, X. (2023). Microbial signature of intestine in children with allergic rhinitis. Frontiers in microbiology, 14, 1208816. https://doi.org/10.3389/fmicb.2023.1208816

36

Darmmikrobiom und verschiedene Erkrankungen

Afzaal, M., Saeed, F., Shah, Y. A., Hussain, M., Rabail, R., Socol, C. T., Hassoun, A., Pateiro, M., Lorenzo, J. M., Rusu, A. V., & Aadil, R. M. (2022). Human gut microbiota in health and disease: Unveiling the relationship. Frontiers in microbiology, 13, 999001. https://doi.org/10.3389/fmicb.2022.999001

37

Darmdurchlässigkeit in Darmerkrankungen und Methoden um sie zu bestimmen

Vanuytsel, T., Tack, J., & Farre, R. (2021). The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation. Frontiers in nutrition, 8, 717925. https://doi.org/10.3389/fnut.2021.717925

38

Bedeutung von regulatorische T-Zellen für Allergietherapien

Palomares, O., Akdis, M., Martín-Fontecha, M., & Akdis, C. A. (2017). Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells. Immunological reviews, 278(1), 219–236. https://doi.org/10.1111/imr.12555

39

American Gut Project zeigt Verbindung zwischen Allergien bei Erwachsenen und Darmmikrobiom

Hua, X., Goedert, J. J., Pu, A., Yu, G., & Shi, J. (2015). Allergy associations with the adult fecal microbiota: Analysis of the American Gut Project. EBioMedicine, 3, 172–179. https://doi.org/10.1016/j.ebiom.2015.11.038

40

Aktuelle Methoden um Darmdurchlässigkeit zu messen

Schoultz, I., & Keita, Å. V. (2020). The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability. Cells, 9(8), 1909. https://doi.org/10.3390/cells9081909

1

Zerstörung der Darmbarriere durch erhöhte Aktivität von Enzymen verursacht Symptome in RDS-C

Annaházi, A., Ferrier, L., Bézirard, V., Lévêque, M., Eutamène, H., Ait-Belgnaoui, A., Coëffier, M., Ducrotté, P., Róka, R., Inczefi, O., Gecse, K., Rosztóczy, A., Molnár, T., Ringel-Kulka, T., Ringel, Y., Piche, T., Theodorou, V., Wittmann, T., & Bueno, L. (2013). Luminal cysteine-proteases degrade colonic tight junction structure and are responsible for abdominal pain in constipation-predominant IBS. The American journal of gastroenterology, 108(8), 1322–1331. https://doi.org/10.1038/ajg.2013.152

2

Veränderungen des Darmmikrobioms bei Kindern mit allergischen Atemwegserkrankungen

Wan, J., Song, J., Lv, Q., Zhang, H., Xiang, Q., Dai, H., Zheng, H., Lin, X., & Zhang, W. (2023). Alterations in the Gut Microbiome of Young Children with Airway Allergic Disease Revealed by Next-Generation Sequencing. Journal of asthma and allergy, 16, 961–972. https://doi.org/10.2147/JAA.S422537

3

Verbindung zwischen Darmbakterien und allergischen Erkrankungen

Han, P., Gu, J. Q., Li, L. S., Wang, X. Y., Wang, H. T., Wang, Y., Chang, C., & Sun, J. L. (2021). The Association Between Intestinal Bacteria and Allergic Diseases-Cause or Consequence?. Frontiers in cellular and infection microbiology, 11, 650893. https://doi.org/10.3389/fcimb.2021.650893

4

Techniken und Biomarker um Darmdurchlässigkeit non-invasiv zu messen

Perez-Diaz-Del-Campo, N., Castelnuovo, G., Ribaldone, D. G., & Caviglia, G. P. (2023). Fecal and Circulating Biomarkers for the Non-Invasive Assessment of Intestinal Permeability. Diagnostics (Basel, Switzerland), 13(11), 1976. https://doi.org/10.3390/diagnostics13111976

5

Studie zur Adhesionsfähigkeit von B. bifidum MIMBb75 an Darmzellen

Guglielmetti, S., Tamagnini, I., Mora, D., Minuzzo, M., Scarafoni, A., Arioli, S., Hellman, J., Karp, M., & Parini, C. (2008). Implication of an outer surface lipoprotein in adhesion of Bifidobacterium bifidum to Caco-2 cells. Applied and environmental microbiology, 74(15), 4695–4702. https://doi.org/10.1128/AEM.00124-08

6

Studie II zur Adhesionsfähigkeit von B. bifidum MIMBb75 an Darmzellen

Guglielmetti, S., Tamagnini, I., Minuzzo, M., Arioli, S., Parini, C., Comelli, E., & Mora, D. (2009). Study of the adhesion of Bifidobacterium bifidum MIMBb75 to human intestinal cell lines. Current microbiology, 59(2), 167–172. https://doi.org/10.1007/s00284-009-9415-x

7

Strukturelle Veränderungen der Darmbarriere stehen in Verbindung mit Symptomeschwere beim RDS-Subtyp alternierende Symptome

Wilcz-Villega, E., McClean, S., & O'Sullivan, M. (2014). Reduced E-cadherin expression is associated with abdominal pain and symptom duration in a study of alternating and diarrhea predominant IBS. Neurogastroenterology and motility, 26(3), 316–325. https://doi.org/10.1111/nmo.12262

8

Stoffwechselprodukte von Darmbakterien modulieren Treg-Zellen

Calvo-Barreiro, L., Zhang, L., Abdel-Rahman, S. A., Naik, S. P., & Gabr, M. (2023). Gut Microbial-Derived Metabolites as Immune Modulators of T Helper 17 and Regulatory T Cells. International journal of molecular sciences, 24(2), 1806. https://doi.org/10.3390/ijms24021806

9

Sichtbare strukturelle Veränderungen der Darmbarriere im Durchfall-prädominaten Reizdarmsyndrom

Martínez, C., Lobo, B., Pigrau, M., Ramos, L., González-Castro, A. M., Alonso, C., Guilarte, M., Guilá, M., de Torres, I., Azpiroz, F., Santos, J., & Vicario, M. (2013). Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier. Gut, 62(8), 1160–1168. https://doi.org/10.1136/gutjnl-2012-302093

10

Sichtbare Lücken in der Darmbarriere beim Reizdarmsyndrom festgestellt mit konfokaler Laser-Endomikroskopie

Turcotte, J. F., Kao, D., Mah, S. J., Claggett, B., Saltzman, J. R., Fedorak, R. N., & Liu, J. J. (2013). Breaks in the wall: increased gaps in the intestinal epithelium of irritable bowel syndrome patients identified by confocal laser endomicroscopy (with videos). Gastrointestinal endoscopy, 77(4), 624–630. https://doi.org/10.1016/j.gie.2012.11.006

11

Probiotika modulieren Immunreaktionen in allergischen Erkrankungen

Eslami, M., Bahar, A., Keikha, M., Karbalaei, M., Kobyliak, N. M., & Yousefi, B. (2020). Probiotics function and modulation of the immune system in allergic diseases. Allergologia et immunopathologia, 48(6), 771–788. https://doi.org/10.1016/j.aller.2020.04.005

12

Probiotika in der Behandlung von allergischer Rhinitis

Luo, C., Peng, S., Li, M., Ao, X., & Liu, Z. (2022). The Efficacy and Safety of Probiotics for Allergic Rhinitis: A Systematic Review and Meta-Analysis. Frontiers in immunology, 13, 848279. https://doi.org/10.3389/fimmu.2022.848279

13

Probiotika

Kim, S. K., Guevarra, R. B., Kim, Y. T., Kwon, J., Kim, H., Cho, J. H., Kim, H. B., & Lee, J. H. (2019). Role of Probiotics in Human Gut Microbiome-Associated Diseases. Journal of microbiology and biotechnology, 29(9), 1335–1340. https://doi.org/10.4014/jmb.1906.06064

14

Messen von Darmwanddurchlässigkeit mit moderner transkutaner Floureszenzspektroskopie

Gan, J., Monfort Sánchez, E., Avery, J., Barbouti, O., Hoare, J., Ashrafian, H., Darzi, A., & Thompson, A. J. (2022). Non-invasive assessment of intestinal permeability in healthy volunteers using transcutaneous fluorescence spectroscopy. Methods and applications in fluorescence, 10(4), 10.1088/2050-6120/ac9513. https://doi.org/10.1088/2050-6120/ac9513

15

Laktobazillen in der Behandlung von allergischer Rhinitis

Steiner, N. C., & Lorentz, A. (2021). Probiotic Potential of Lactobacillus Species in Allergic Rhinitis. International archives of allergy and immunology, 182(9), 807–818. https://doi.org/10.1159/000515352

16

Klinische Studie zur Behandlung des Reizdarmsyndroms mit B. bifidum MIMBb75 (lebender Stamm)

Guglielmetti, S., Mora, D., Gschwender, M., & Popp, K. (2011). Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life--a double-blind, placebo-controlled study. Alimentary pharmacology & therapeutics, 33(10), 1123–1132. https://doi.org/10.1111/j.1365-2036.2011.04633.x

17

Klinische Studie zur Behandlung des Reizdarmsyndroms mit B. bifidum HI-MIMBb75

Andresen, V., Gschossmann, J., & Layer, P. (2020). Heat-inactivated Bifidobacterium bifidum MIMBb75 (SYN-HI-001) in the treatment of irritable bowel syndrome: a multicentre, randomised, double-blind, placebo-controlled clinical trial. The lancet. Gastroenterology & hepatology, 5(7), 658–666. https://doi.org/10.1016/S2468-1253(20)30056-X

18

Immunmechanismen von Allergien und die Rolle der regulatorischen T-Zellen

Calzada, D., Baos, S., Cremades-Jimeno, L., & Cárdaba, B. (2018). Immunological Mechanisms in Allergic Diseases and Allergen Tolerance: The Role of Treg Cells. Journal of immunology research, 2018, 6012053. https://doi.org/10.1155/2018/6012053

19

Erhöhte Darmwanddurchlässigkeit und Schmerzempfindlichkeit beim Durchfall-prädomonaten Reizdarmsyndrom

Zhou, Q., Zhang, B., & Verne, G. N. (2009). Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome. Pain, 146(1-2), 41–46. https://doi.org/10.1016/j.pain.2009.06.017

20

Erhöhte Darmwanddurchlässigkeit steht in Verbindung mit Stuhlhäufigkeit beim Durchfall-prädomonaten Reizdarmsyndrom

Gecse, K., Róka, R., Séra, T., Rosztóczy, A., Annaházi, A., Izbéki, F., Nagy, F., Molnár, T., Szepes, Z., Pávics, L., Bueno, L., & Wittmann, T. (2012). Leaky gut in patients with diarrhea-predominant irritable bowel syndrome and inactive ulcerative colitis. Digestion, 85(1), 40–46. https://doi.org/10.1159/000333083

21

Eigenschaften des Darmmikrobioms von Erwachsenen mit allergischer Rhinits

Zhu, L., Xu, F., Wan, W., Yu, B., Tang, L., Yang, Y., Du, Y., Chen, Z., & Xu, H. (2020). Gut microbial characteristics of adult patients with allergy rhinitis. Microbial cell factories, 19(1), 171. https://doi.org/10.1186/s12934-020-01430-0

22

Effektivität von Probiotika in der Behandlung von Kindern mit allergischer Rhinits

Wang, X., Tan, X., & Zhou, J. (2022). Effectiveness and safety of probiotic therapy for pediatric allergic rhinitis management: A systematic review and meta-analysis. International journal of pediatric otorhinolaryngology, 162, 111300. https://doi.org/10.1016/j.ijporl.2022.111300

23

Effektivität und Sicherheit von Mikrobiomsupplementation in der Behandlung von allergischer Rhinitis

Liu, D., Wang, X., & Zhang, H. (2023). Efficacy and safety of gastrointestinal microbiome supplementation for allergic rhinitis: A systematic review and meta-analysis with trial sequential analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology, 118, 154948. https://doi.org/10.1016/j.phymed.2023.154948

24

Dysbiose verursacht nachhältige Veränderungen der Treg-Zellen im Körper

Zhang, X., Borbet, T. C., Fallegger, A., Wipperman, M. F., Blaser, M. J., & Müller, A. (2021). An Antibiotic-Impacted Microbiota Compromises the Development of Colonic Regulatory T Cells and Predisposes to Dysregulated Immune Responses. mBio, 12(1), e03335-20. https://doi.org/10.1128/mBio.03335-20

25

Dysbiose verursacht allergische Immunantworten

Augustine, T., Kumar, M., Al Khodor, S., & van Panhuys, N. (2023). Microbial Dysbiosis Tunes the Immune Response Towards Allergic Disease Outcomes. Clinical reviews in allergy & immunology, 65(1), 43–71. https://doi.org/10.1007/s12016-022-08939-9

26

Die Rolle von regulatorischen T-Zellen in Allergien

Noval Rivas, M., & Chatila, T. A. (2016). Regulatory T cells in allergic diseases. The Journal of allergy and clinical immunology, 138(3), 639–652. https://doi.org/10.1016/j.jaci.2016.06.003

27

Die Rolle von regulatorischen T-Zellen in Allergien

Pellerin, L., Jenks, J. A., Bégin, P., Bacchetta, R., & Nadeau, K. C. (2014). Regulatory T cells and their roles in immune dysregulation and allergy. Immunologic research, 58(2-3), 358–368. https://doi.org/10.1007/s12026-014-8512-5

28

Die Adhäsion von Bifidobakterien an Darmgewebe

Westermann, C., Gleinser, M., Corr, S. C., & Riedel, C. U. (2016). A Critical Evaluation of Bifidobacterial Adhesion to the Host Tissue. Frontiers in microbiology, 7, 1220. https://doi.org/10.3389/fmicb.2016.01220

29

Die Adhäsion von B. bifidum MIMBb75 an Darmzellen wird nicht durch das bakterielle Oberflächenprotein BopA bestimmt, sondern beruht auf hydrophober Anziehung

Kainulainen, V., Reunanen, J., Hiippala, K., Guglielmetti, S., Vesterlund, S., Palva, A., & Satokari, R. (2013). BopA does not have a major role in the adhesion of Bifidobacterium bifidum to intestinal epithelial cells, extracellular matrix proteins, and mucus. Applied and environmental microbiology, 79(22), 6989–6997. https://doi.org/10.1128/AEM.01993-13

30

Der Zusammenhang von erhöhter Darmpermeabilität, Entzündung und Schmerzen beim Reizdarmsyndrom

Camilleri, M., Lasch, K., & Zhou, W. (2012). Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome. American journal of physiology. Gastrointestinal and liver physiology, 303(7), G775–G785. https://doi.org/10.1152/ajpgi.00155.2012

31

Der Einfluss von Rauchen auf das Mikrobiom

Shapiro, H., Goldenberg, K., Ratiner, K., & Elinav, E. (2022). Smoking-induced microbial dysbiosis in health and disease. Clinical science (London, England : 1979), 136(18), 1371–1387. https://doi.org/10.1042/CS20220175

32

Der Effekt des Darmmikrobioms und Probiotika auf Gewicht und Fettleibigkeit

Aoun, A., Darwish, F., & Hamod, N. (2020). The Influence of the Gut Microbiome on Obesity in Adults and the Role of Probiotics, Prebiotics, and Synbiotics for Weight Loss. Preventive nutrition and food science, 25(2), 113–123. https://doi.org/10.3746/pnf.2020.25.2.113

33

Das Darmmikrobiom von Erwachsenen mit allergischer Rhinits ist weniger divers und hat eine reduzierte Vielfalt von Schlüsselbakterien

Watts, A. M., West, N. P., Zhang, P., Smith, P. K., Cripps, A. W., & Cox, A. J. (2021). The Gut Microbiome of Adults with Allergic Rhinitis Is Characterised by Reduced Diversity and an Altered Abundance of Key Microbial Taxa Compared to Controls. International archives of allergy and immunology, 182(2), 94–105. https://doi.org/10.1159/000510536

34

Das Darmmikrobiom in allergischer Rhinits unterscheidet sich von anderen allergischen Erkrankungen

Su, Y. J., Luo, S. D., Hsu, C. Y., & Kuo, H. C. (2021). Differences in gut microbiota between allergic rhinitis, atopic dermatitis, and skin urticaria: A pilot study. Medicine, 100(9), e25091. https://doi.org/10.1097/MD.0000000000025091

35

Darmmikrobiomsignaturen von Kindern mit allergischer Rhinitis

Zhang, P., Zhou, X., Tan, H., Jian, F., Jing, Z., Wu, H., Zhang, Y., Luo, J., Zhang, J., & Sun, X. (2023). Microbial signature of intestine in children with allergic rhinitis. Frontiers in microbiology, 14, 1208816. https://doi.org/10.3389/fmicb.2023.1208816

36

Darmmikrobiom und verschiedene Erkrankungen

Afzaal, M., Saeed, F., Shah, Y. A., Hussain, M., Rabail, R., Socol, C. T., Hassoun, A., Pateiro, M., Lorenzo, J. M., Rusu, A. V., & Aadil, R. M. (2022). Human gut microbiota in health and disease: Unveiling the relationship. Frontiers in microbiology, 13, 999001. https://doi.org/10.3389/fmicb.2022.999001

37

Darmdurchlässigkeit in Darmerkrankungen und Methoden um sie zu bestimmen

Vanuytsel, T., Tack, J., & Farre, R. (2021). The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation. Frontiers in nutrition, 8, 717925. https://doi.org/10.3389/fnut.2021.717925

38

Bedeutung von regulatorische T-Zellen für Allergietherapien

Palomares, O., Akdis, M., Martín-Fontecha, M., & Akdis, C. A. (2017). Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells. Immunological reviews, 278(1), 219–236. https://doi.org/10.1111/imr.12555

39

American Gut Project zeigt Verbindung zwischen Allergien bei Erwachsenen und Darmmikrobiom

Hua, X., Goedert, J. J., Pu, A., Yu, G., & Shi, J. (2015). Allergy associations with the adult fecal microbiota: Analysis of the American Gut Project. EBioMedicine, 3, 172–179. https://doi.org/10.1016/j.ebiom.2015.11.038

40

Aktuelle Methoden um Darmdurchlässigkeit zu messen

Schoultz, I., & Keita, Å. V. (2020). The Intestinal Barrier and Current Techniques for the Assessment of Gut Permeability. Cells, 9(8), 1909. https://doi.org/10.3390/cells9081909